invasion cards mtg march of the machines Alara // Awaken Maelstrom [March of the Machine] you may play cards exiled this way March of the Machine Card

Night's Whisper might do much the same for your card advantage situation for the mana and it wouldn't becomes useless as your opponent consumed their hand but that is entirely overlooking the disruption caused by discard

But more spoilers have appeared, and we now know there's a named -1/-1 mechanic, Blight

The main drawback to these strategies is that gaining life doesnt impact the board, which can lead to a bunch of dead draws

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Iron Verdict is a nice bit of removal, dealing five damage to a target tapped creature for just one mana, filling a similar niche to the likes of Swift Response from older sets